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The Physical Singularity of Life - A statistical mechanics for biology| old_uid | 16225 |
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| title | The Physical Singularity of Life - A statistical mechanics for biology |
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| start_date | 2018/09/11 |
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| schedule | 18h30-20h30 |
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| online | no |
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| location_info | salle 1.1 |
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| details | Happy Hour Conference |
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| summary | Ontogeny is controlled by a genetic regulatory network. The alternative dynamical attractors of this network constitute the different cell types. For fifty years, Boolean networks have been used as good models of such regulatory networks. Ensembles of Boolean networks behave in three regimes: ordered, critical, and chaotic. It now appears that real genetic regulatory networks, under the drive of selection, have achieved the critical regime. The generic properties of this regime stand as a new kind of statistical mechanics for biology. These properties include homeostasis, restricted pathways of differentiation, and a scaling law: the number of cell types should increase as a power law with respect to DNA per cell (hence variables in the corresponding network.) The predicted power law slope is 0.63. The observed scaling is, in fact, a power law, the slope is 0.88. We believe a statistical mechanics that hopes to explain features of organism by the generic properties of the critical sub ensemble of boolean networks, may be highly valuable. |
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| responsibles | Cazalis, Mesmoudi |
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