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Is Memory Stored in Synapses| old_uid | 16313 |
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| title | Is Memory Stored in Synapses |
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| start_date | 2018/09/18 |
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| schedule | 12h15 |
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| online | no |
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| location_info | salle de Conférence |
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| details | séminaire axe neuro |
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| summary | The biological basis of the engram, the physical memory trace, remains opaque. It is widely believed that long-term memories are stored as changes in the strengths of synaptic connections in the brain. This neurobiological model for the engram, the synaptic plasticity model, has extensive experimental support. Nonetheless, evidence from my laboratory, as well as from other laboratories, has challenged the synaptic plasticity model. In particular, it has been shown that long-term memory can persist, at least partially, in the absence of behavioral and synaptic changes. This “occult” component of memory, which appears to reside in the cell bodies of neurons, permits the full induction of a memory following its disruption by antimnemonic manipulations such as reconsolidation blockade and post-training inhibition of protein synthesis. Here, I will present evidence that long-term memory in Aplysia is stored by epigenetic changes. The epigenetic changes, in turn, may be induced by RNA. In support of this idea, we have recently demonstrated that the long-term memory for sensitization in Aplysia can be transferred from trained to untrained animals by injection of RNA. |
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| responsibles | <not specified> |
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