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Dissecting hippocampal circuit dynamics for navigation and learning| old_uid | 16355 |
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| title | Dissecting hippocampal circuit dynamics for navigation and learning |
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| start_date | 2018/09/24 |
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| schedule | 11h |
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| online | no |
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| details | Invited by Rosa Cossart |
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| summary | Learning and remembering where and when salient events occur in space and time are essential for adaptive behaviors. Both spatial navigation and episodic memory have been linked to the mammalian hippocampus, but the detailed mechanisms at cellular and circuit levels remain poorly understood. To address these questions, we use in vivo functional imaging to monitor the activity of identified excitatory, inhibitory and neuromodulatory circuit motifs in the hippocampus of behaving mice during spatial exploration, fear learning and goal-directed learning. The talk will focus on our recent efforts aimed at dissecting functional roles of multimodal microcircuits at the CA1 output node of the hippocampus. I will present findings on how goal-oriented spatial learning is supported by disinhibitory GABAergic circuits in CA1. I will present our findings related to long-term memory replay and consolidation during sharp wave ripples in the hippocampus. Finally, I will discuss our most recent efforts to dissect hippocampal population dynamics supporting temporal associative learning. |
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| oncancel | Séance annulée ! |
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| responsibles | Bernier |
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