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Cerebello-cortical connectivity in autism spectrum disorder| old_uid | 16510 |
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| title | Cerebello-cortical connectivity in autism spectrum disorder |
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| start_date | 2018/10/01 |
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| schedule | 10h |
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| online | no |
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| details | FUNCONNECT meeting |
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| summary | Introduction : The cerebellum, in conjunction with the cortex, is involved in sensori-motor, cognitive and socio-affective processes, all of which are impaired in ASD. The cerebellar connectivity has been highlighted in functional neuroimaging studies in ASD population. However, patterns of cerebellar connectivity in ASD have been investigated only in small samples and showed inconsistent findings. These discrepant results are common in the ASD litterature and might be explained by the small sample size (typically < 40 individuals with ASD), leading to false positive results.
Methods : We investigated cerebello-cerebro resting-state functional connectivity in a large prospective multicentric sample of 429 individuals with ASD (without intellectual disability) and controls, using independent component analysis and dual regression.
Results. We found an overall increased connectivity between the cognitive component of the cerebellum and widespread cortical regions.
Conclusion : Our results highlight the potential role of the cerebellum in autism. This is to date the largest study investigating cerebello-cerebro connectivity in ASD population. |
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| responsibles | Blancho |
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