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Is Hungtington disease a developmental disorder?| old_uid | 16585 |
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| title | Is Hungtington disease a developmental disorder? |
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| start_date | 2018/10/15 |
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| schedule | 11h-12h |
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| online | no |
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| details | Invitée par Alexandra Durr |
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| summary | The bulk of interest in the huntingtin protein has centered on the fact that, when mutated, huntingtin causes Hungtinton’s disease (HD), a devastating neurological disorder. Given the adult onset and dysfunction and death of adult neurons characterizing HD, most studies have focused on the toxic effects elicited by mutant HTT in adult neurons. However, huntingtin is ubiquitous and expressed in the developing embryo where it plays an essential role. We will discuss how HTT regulates several steps of mouse embryonic corticogenesis, whether these steps are altered in HD and consider the viewing of HD as a developmental disorder. |
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| responsibles | Oliviero |
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