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Internal hippocampal dynamics| old_uid | 16634 |
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| title | Internal hippocampal dynamics |
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| start_date | 2018/10/22 |
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| schedule | 11h |
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| online | no |
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| summary | The hippocampus forms discrete and ordered representations of locations and events in the context in which they occur. We study the functional structure of the hippocampus. Hippocampal dynamics result from the interaction between self-organized internal dynamics (internal mode) and various external inputs from the environment and context. To describe structure-function relationships in hippocampal networks, we have developed an approach that combines in vivo calcium imaging, electrophysiology, neuroanatomy, mathematics, modeling and behavior. We have recently uncovered the spatial organization and lifetime of the basic hippocampal functional units (assemblies) in CA1 in the internal mode (Malvache et al; Science 2016). Such assemblies represent default building blocks that can be reused and combined into sequences of neuronal activation to encode or retrieve information about traveled distance or elapsed time (Villette et al. Neuron 2015). I will present data showing how adult hippocampal dynamics are remarkably stable across days and that early developmental programs may critically contribute to the scaffolding of the hippocampal functional structure. |
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| responsibles | Blancho |
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