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The hair-cell bundle as a mechanoreceptive organelle and amplifier for hearing| old_uid | 16886 |
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| title | The hair-cell bundle as a mechanoreceptive organelle and amplifier for hearing |
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| start_date | 2018/12/11 |
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| schedule | 10h |
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| online | no |
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| details | Séminaire exceptionnel ! Hosted by Adeline Orts-Del Immagine, Claire Wyart lab. |
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| summary | Hearing starts with the deflection of the hair bundle, a cohesive tuft of elongated microvilli ?the stereocilia that protrudes from the apical surface of each sensory hair cell of the inner ear. Sound-evoked vibrations of the hair bundle modulates tension in tip links that interconnect individual stereocilia, giving rise to a transduction current through mechanosensitive ion channels. Remarkably, the hair cell can power spontaneous oscillations of its hair bundle, resulting in frequency-selective amplification of periodic inputs. Oscillations are thought to emerge from a dynamical interplay between the transduction channels and adaptation driven by the activity of molecular motors as well as calcium feedback. In the cochlea, different sound frequencies are detected by different hair cells, which are specially distributed in the organ according to a tonotopic map. Frequency tuning of a given hair cell to a characteristic frequency of the sound input is not fully understood. Still, recent evidence from our group demonstrates that stiffness and tension of the protein complex associated with the tip link increases with the characteristic frequency of the hair cell, suggesting that tonotopic map emerges in part from mechanical gradients of the tip-link complex. |
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| responsibles | Oliviero |
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