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Rnd2: a new player in the regulation of adult hippocampal neurogenesis| old_uid | 17235 |
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| title | Rnd2: a new player in the regulation of adult hippocampal neurogenesis |
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| start_date | 2019/01/30 |
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| schedule | 11h |
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| online | no |
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| location_info | salle Conférence IBCG |
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| details | séminaire axe neuro |
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| summary | Most neurons of the brain are born during embryogenesis. In contrast, the majority of granule neurons in the dentate gyrus are generated at adulthood. Tremendous efforts were initiated to characterize the mechanisms and signaling cascades involved in this process. We examined the role played by RhoGTPases, the master regulators of cytoskeleton rearrangements. We found that deletion of Rnd2 specifically in adult-born hippocampal neurons decreases their survival while the surviving ones, exhibit abnormal morphology and mispositioning. Importantly, this deletion affected mice behavior, identifying Rnd2 as a critical regulator of adult newborn neuron development and function. Moreover, we revealed a differential regulation of developmental and adult neurogenesis in the dentate gyrus. |
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| responsibles | <not specified> |
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