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Activity-dependent imaging of GABA- releasing interneurons in the cerebellar cortex of anesthetized and awake mice| old_uid | 17384 |
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| title | Activity-dependent imaging of GABA- releasing interneurons in the cerebellar cortex of anesthetized and awake mice |
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| start_date | 2019/02/22 |
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| schedule | 12h-13h |
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| online | no |
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| location_info | salle 01-02 |
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| details | Invitée par Javier Zorrilla de San Martin |
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| summary | In the murine cerebellum, molecular layer interneurons (MLI) connect to each other by chemical and electrical synapses and, through lateral and feed-forward inhibition, control the spike rate of Purkinje cells. I will describe our recent studies of this interconnected MLI circuit using genetically-encoded calcium proteins and 2 photon imaging. In anesthetized mice, the studies provide a first characterization of the temporal and spatial pattern of activity of the MLI network, as well as the signaling mechanisms underlying the calcium rises induced by electrical stimulation of parallel fibers. In awake mice, our studies show that the MLI network engages in synchronized activity when mice perform rhythmic licking and point to a potential influence of MLIs in anticipating the behavioral performance. |
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| responsibles | Oliviero |
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