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Neurocognitive impact of juvenile obesity: evidence from animal models| old_uid | 17588 |
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| title | Neurocognitive impact of juvenile obesity: evidence from animal models |
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| start_date | 2019/03/13 |
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| schedule | 16h30 |
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| online | no |
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| location_info | salle de conférence Vandel |
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| details | séminaire axe neuro |
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| summary | In addition to metabolic and cardiovascular disorders, obesity is associated with cognitive disorders in humans. Growing prevalence of obesity during adolescence is particularly alarming since it is a decisive period for maturation of the hippocampus and the amygdala, both required for shaping neurocognitive function for the whole life duration. Using animal models, we demonstrated that obesogenic diet (high-fat diet, HFD) consumption during adolescence has more detrimental impact on memory and brain plasticity than HFD intake at adulthood. Surprisingly, we found that adolescent HFD affects both memory and plasticity in a bidirectional way, impairing hippocampal function but enhancing amygdala function. As mechanisms involved, we revealed that deregulation of inflammatory, glucocorticoid (HPA axis) and more recently endocannabinoid systems are central in these memory alterations. We are currently focusing on disruption of amygdala-hippocampal connectivity as well as circadian feeding pattern that could also participate in juvenile HFD-induced adverse neurocognitive outcomes. Collectively, these results suggest that adolescence represents a period of increased vulnerability to the effects of obesogenic diet consumption that may promote maladaptive cognitive processing later in life. |
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| responsibles | <not specified> |
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