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Slit-Robo signaling links synapse specificity with functional circuit wiring| old_uid | 17762 |
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| title | Slit-Robo signaling links synapse specificity with functional circuit wiring |
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| start_date | 2019/09/23 |
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| schedule | 11h |
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| online | no |
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| summary | The thousands of connections made by each of neuron in our brain underlie our ability to perceive and interact with our environment. Neural circuits are wired up during development by virtue of a molecular code that allows individual neurons to find their correct connection partners. Given their functional significance, even subtle defects in the developmental mechanisms establishing synaptic connections are thought to underlie many neurodevelopmental disorders including autism spectrum disorders, Tourette syndrome, schizophrenia and epilepsy. Therefore, investigating the molecular mechanisms underlying the assembly of the connectome of functional neural circuits is highly significant. I will report results identifying a new function for the well-studied axon guidance proteins Robo receptors and its ligand, the leucine-rich repeat (LRR) domaincontaining Slit, as synaptogenic molecules underlying the formation of excitatory synapses in hippocampal circuits important for learning and memory. |
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| responsibles | Bernier |
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