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Real-time fMRI neurofeedback as treatment for inter-critical mood symptoms in bipolar disorder: a randomized controlled trial, by Josselin Houenou - Pauline Favre / NeuroSpin UNIACT| old_uid | 17942 |
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| title | Real-time fMRI neurofeedback as treatment for inter-critical mood symptoms in bipolar disorder: a randomized controlled trial, by Josselin Houenou - Pauline Favre / NeuroSpin UNIACT |
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| start_date | 2019/10/14 |
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| schedule | 11h |
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| online | no |
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| summary | Bipolar Disorder (BD) is a severe mood disorder affecting between 1% and 3% of the general population. It is characterized by the succession of depressive and manic episodes, with periods of stabilization during which patients may present “residual” depressive or anxious symptoms, which are characterized by sadness and emotional hyper-reactivity. Although subthreshold, these residual symptoms are very disabling for their daily lives and are associated with the risk of recurrence and poor global functioning. The effect of pharmacological and psychotherapeutic treatments is demonstrated in the management of acute episodes but remains insufficient on residual symptoms. Therefore, there are so far few therapeutic options to target the inter-episode residual symptoms in BD. One novel approach is the real-time functional magnetic resonance imaging (fMRI) neurofeedback (NFB), which has already been shown to be an efficient method for self-regulating brain function, behavior and treating depression. The muli-centric study we are presenting aims at assessing the efficacy of 3-weeks neurofeedback training with real-time fMRI on the treatment of residual mood symptoms in patients with BD. We will specifically target depressive symptoms by training the patients to decrease the amygdala’s hemodynamic response to emotional stimuli. In this talk, we will present the theoretical background, the objectives and the detailed protocol of the study we aim to conduce at Neurospin. |
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| responsibles | Blancho |
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