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Elucidating the contribution of hippocampus and adult neurogenesis to the stress response and antidepressant effects, by Alexandre SURGET, UMR Inserm U 1253 - iBrain - Psychiatrie Neuro-Fonctionnelle, Tours, Fr| old_uid | 17991 |
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| title | Elucidating the contribution of hippocampus and adult neurogenesis to the stress response and antidepressant effects, by Alexandre SURGET, UMR Inserm U 1253 - iBrain - Psychiatrie Neuro-Fonctionnelle, Tours, Fr |
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| start_date | 2019/10/30 |
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| schedule | 11h30 |
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| online | no |
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| summary | Stress is not always detrimental: it promotes adaptation, drives motivation or helps individuals to perform better and to deal with challenging experiences. However, when it becomes excessive or chronic, stress can lead to the emergence of pathophysiological conditions. Despite solid progress in the last decade, the precise mechanisms causing their pathophysiology and remission remain poorly understood. Using animal models and translational studies, we are investigating the neurobiological mechanisms underlying stress integration, stress-related disorders and their treatments, focusing mostly on hippocampus. One major dévelopment of our works rests on unravelling the functional involvement of hippocampal neurogenesis in stress response and antidepressant effects, specifically we demonstrated how adult-generated neurons are recruited by antidepressants to rescue the hippocampal control on HPA axis under stress. Our current research aims to provide a mechanistic framework explaining population dynamics within the hippocampal formation, and how these circuits operate into larger systems to produce normal and pathological brain functions. |
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| responsibles | IBCG |
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