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Interplay between dopamine and prefrontal cortex in self-paced decisions| old_uid | 18637 |
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| title | Interplay between dopamine and prefrontal cortex in self-paced decisions |
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| start_date | 2021/01/12 |
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| schedule | 12h15 |
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| online | no |
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| location_info | salle de conférence + zoom |
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| details | https://univ-tlse3fr.zoom.us/j/84194915547?pwd=c3RFZVg1b05ETDZJOVlxTUFqK0JQQT09
ID de réunion: 841 9491 5547
Code secret: 358261 |
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| summary | Daily decisions are often self-generated, motivated by our goals rather than triggered by a stimulus. The neuromodulator dopamine is classically implicated in the learning of stimulus-triggered actions leading to rewards. Dopamine also affects self-paced decisions, probably through its interaction with frontal areas of the cortex. How self-paced decisions emerge from the dynamics of this meso-cortical circuit remains unclear. We addressed this question in a sequential decision task for mice allowing a combination of multisite electrophysiological recordings, computational modeling and perturbation techniques. In this talk I will show two lines of results : how a distributed sequence of mesocortical activity may be causally linked to decisions, and how dopamine may exert an online regulation of frontal dynamics. |
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| responsibles | <not specified> |
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