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The strange developmental trajectory of embryonic Renshaw cells| old_uid | 18819 |
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| title | The strange developmental trajectory of embryonic Renshaw cells |
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| start_date | 2021/03/01 |
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| schedule | 14h30-17h |
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| online | no |
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| summary | It is classically admitted that neurons are barely excitable when they reach their final location in the CNS, become later capable of firing tonically action potentials and eventually acquire their mature discharge pattern when they enrich their repertoire of membrane conductances. Combining electrophysiological experiments and theoretical analysis, we show that embryonic Renshaw cells do not follow this pattern of development. They are already excitable when they reach their final position in the spinal cord and participate to spontaneous network activity. They loose then their ability to fire actions potentials that they recover later when locomotor-like activity emerges. This unusual evolution of the firing properties is controlled by a persistent current sodium current and a delayed rectifier potassium current, calcium and calcium-dependent conductances being not expressed at this age. These results show that the classical dogma on the development of embryonic neurons must be reconsidered and that neuronal development is closely linked to the activity pattern and function of the network in which they are embedded. |
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| responsibles | Agulhon |
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