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Excitatory Interneurons Linked to Locomotor Rhythm Generation : Circuit Changes during Postnatal Development and Following SCI| old_uid | 18895 |
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| title | Excitatory Interneurons Linked to Locomotor Rhythm Generation : Circuit Changes during Postnatal Development and Following SCI |
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| start_date | 2021/03/19 |
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| schedule | 13h30 |
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| online | no |
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| details | Invité par le PhD Program Neuroschool (Benoist Drouillas, INT P3M)-contacter le Risc pour la connexion : risc@risc.cnrs.fr |
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| summary | To initiate and support locomotion, rhythm generating neurons in the spinal cord convert descending input into a rhythmic signal which is conveyed to downstream neurons, leading to the recruitment of motor neurons and the activation of muscles. Although neurons necessary for various aspects of locomotion have been identified, spinal rhythm generating remained elusive. Neurons expressing the transcription factor Shox2 during development are a candidate rhythm generating population. These neurons have many characteristics of rhythm generating neurons and genetic silencing of the population leads to an effect on the locomotor rhythm. More recent work aimed at determining mechanisms underlying spinal rhythmogenesis has focused on network activity and interconnectivity within the Shox2 neuron population and findings suggest that there may be a shift in rhythmic mechanisms with circuit maturation. Additionally, the excitability of Shox2 neurons does not change after spinal cord injury but the sensory afferent information to them is substantially altered after injury and by therapeutic intervention. By determining both the developmental and experience-related changes in the properties and connectivity of Shox2 neurons, targets for restoration of locomotor function following injury and in developmental motor disorders may be revealed. |
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| responsibles | Riehle |
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