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Polygenic risk for psychiatric disorders and postmortem co-expression provide different perspectives on the relationship between genetic variation and cognition| old_uid | 18914 |
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| title | Polygenic risk for psychiatric disorders and postmortem co-expression provide different perspectives on the relationship between genetic variation and cognition |
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| start_date | 2021/03/26 |
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| schedule | 11h30-12h30 |
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| online | no |
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| details | On Zoom. Link will be sent my email. https://www.bordeaux-neurocampus.fr/event/webinar-giulio-pergola/ - Invited by Susanna Pietropaolo (INCIA) |
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| summary | The talk will give a general perspective on polygenic risk and use the publication A miR-137-related biological pathway of risk for Schizophrenia is associated with human brain emotion processing as a case study.
Genome-Wide-Association studies have involved miR-137 in schizophrenia. However, the biology underlying this statistical evidence is unclear. Statistical polygenic risk for schizophrenia is associated with working memory, while other biological evidence involves miR-137 in emotion processing. We investigated the function of miR-137 target schizophrenia risk genes in humans.
We identified a prefrontal co-expression pathway of schizophrenia-associated miR-137 targets and validated the association with miR-137 expression in neuroblastoma cells. Alleles predicting greater co-expression of this pathway were associated with greater prefrontal activation during emotion processing in two independent cohorts of healthy volunteers (N1=222; N2=136). Statistical polygenic risk for schizophrenia was instead associated with prefrontal activation during working memory.
A co-expression pathway links miR-137 and its target genes to emotion processing and risk for schizophrenia. Low prefrontal miR-137 expression may be related with SCZ risk via increased expression of target risk genes, itself associated with increased prefrontal activation during emotion processing. |
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| oncancel | En ligne |
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| responsibles | Deris |
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