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Deamidation of human serum albumin and its possible role in Alzheimer’s disease etiology| old_uid | 19699 |
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| title | Deamidation of human serum albumin and its possible role in Alzheimer’s disease etiology |
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| start_date | 2021/11/18 |
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| schedule | 14h-15h30 |
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| online | no |
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| summary | Human serum albumin (HSA) is the most abundant protein in blood accounting for more than half of the protein content. HSA performs several important functions, such as transporting molecules from blood-brain-barrier to kidneys and liver for clearance. We found that asparagine deamidation leading to isoasparate formation causes structural changes in HSA and triggers its aggregation, with greatly diminished carrying capacity for both monomers and aggregates. A link is found between the level of deamidated HSA and the development of Alzheimer’s disease (AD), providing a new promising venue for AD research after the failure of anti-Aß drugs to slow down AD development. |
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| responsibles | Deris |
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