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Metabolic regulation of memory formation in Drosophilatitle | Metabolic regulation of memory formation in Drosophila |
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start_date | 2022/06/29 |
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schedule | 11h |
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online | no |
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location_info | amphithéâtre |
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summary | Essential brain functions, such as forming long-term memoy (LTM), acutely
increase the energetic burden of implicated neuronal circuits, as shown in many species
from Drosophila flies to humans. Thus, inability of meeting such fast demands results in
pathological states that can range from loss of circuit coding precision to reduced survival. In
neurons, mitochondria provide most of the required energy for neuronal function. The
primary metabolite consumed by mitochondria is pyruvate, derived from glucose, which
fuels the tricarboxylic acid cycle. Currently we miss a global picture of how energy
metabolism intervene in higher brain functions such as memory.
Drosophila, despite having a much simpler brain compared to mammalian models, can
feature elaborated memory processes involving well-described neuronal networks.
Moreover, our lab has developed pioneer 2-photon imaging protocols to measure in vivo
intracellular metabolic fluxes in neurons (1,2) using genetically-encoded FRET metabolic
sensors. Using this model, we showed that an acute upregulation of mitochondrial pyruvate
uptake within the fly’s major memory center, the mushroom body (MB), is both necessary
and sufficient to drive LTM formation (3). This establishes mitochondria as an unexpected
critical regulatory checkpoint in the formation of LTM. But how do mitochondria exert such a
control, and how is pyruvate provided to mitochondria for memory fueling?
Our recent results show that glial cells are essential in providing pyruvate to neurons,
establishing in vivo that the nature of the of neuron-glia metabolic coupling is key in
determining memory persistence and properties. |
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responsibles | CRNL |
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Workflow historyfrom state (1) | to state | comment | date |
submitted | published | | 2022/06/23 10:36 UTC |
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