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Dopamine: a teaching signal triggering hippocampal long‑term potentiation and contextual learning| title | Dopamine: a teaching signal triggering hippocampal long‑term potentiation and contextual learning |
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| start_date | 2024/12/17 |
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| schedule | 11h |
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| online | no |
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| location_info | / |
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| summary | Long term potentiation (LTP) is one of the mechanisms underlying learning and memory. However, a hippocampus relying purely on Hebbian rules should encode every single event, which does not seems to be the case. This led theoreticians to propose a NeoHebbian framework in which the conjunction between pre- and post-synaptic activity requires a third factor – a neuromodulator playing the role of a teaching signal – in order to trigger long lasting synaptic plasticity. We used electrophysiology, optogenetics and behavior to show that VTA dopamine neurons innervating the hippocampus can operate as a teaching signal that triggers NeoHebbian LTP and promotes contextual learning. |
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| responsibles | NC |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2024/12/05 16:06 UTC |
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