The perils of epistemic misalignment in contemporary microbiome science

titleThe perils of epistemic misalignment in contemporary microbiome science
start_date2022/09/19
schedule14h-16h
onlineyes
location_infosalle de conférence
summaryThis talk will explore the use of 16S rRNA as the most frequent sequencing technology in contemporary microbiome science. I track the historical origins of 16S rRNA to show that it was designed to track bacterial phylogeny. After this, I show that a big class of research endevours where 16S rRNA is frequently used to study the microbiome are driven by questions for which bacterial phylogeny is irrelevant, producing what I call an epistemic misalignment between a research question and the methods used to investigate it. I content that this epistemic misalignment is part of what has driven some of the criticisms to microbiome science. Finally, drawing on this, I defend the necessity of knowing the specific research questions that a research method was designed to answer to avoid epistemic misalignment and risk the possibility of scientific failure.
responsiblesMontjean, Delettre, Haas