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Neural arithmetic for stress response| title | Neural arithmetic for stress response |
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| start_date | 2025/06/13 |
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| schedule | 11h30 |
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| online | no |
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| location_info | NC |
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| summary | The stress response represents a shift in neural operations—from maintaining homeostasis to executing emergency responses—affecting a wide range of behavioral and physiological functions. A classic example is the activation of the hypothalamic-pituitary-adrenal (HPA) axis, which increases systemic glucocorticoid levels from baseline to stress-elevated concentrations. Despite decades of research, the neural mechanisms underlying this transition remain poorly understood.
Using a combination of in vivo and ex vivo electrophysiology in mice, along with computational modeling, we identified a key circuit mechanism that enables rapid transitions in the activity states of corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus—critical regulators of the HPA axis. I will present our findings on how local GABAergic feedback circuits tightly constrain the gain (i.e., arithmetic transformation) of CRHPVN neurons under non-stress conditions. Stress removes this inhibitory control, allowing for the robust activation of CRHPVN neurons. Together, our work reveals a neural arithmetic and circuit-level framework for understanding the hormonal stress response. |
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| responsibles | NC |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2025/06/02 10:49 UTC |
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