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Exploring cortical excitatory/inhibitory and hippocampal dysfunction in psychosisAdams| title | Exploring cortical excitatory/inhibitory and hippocampal dysfunction in psychosisAdams |
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| start_date | 2025/06/23 |
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| schedule | 15h15 |
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| online | no |
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| location_info | Room B10 |
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| summary | This talk will present two recent lines of research. First, excitatory/inhibitory imbalance in cortical circuits in schizophrenia has been suspected for several decades, but the details of this imbalance remain opaque. For example, is the imbalance E>I or E<I? Is it the same in all potential subgroups within psychosis? Is it the same throughout the course of the illness - including in the prodrome (before the illness is diagnosed)? Does it predict conversion to psychosis? Do symptoms relate to the primary pathology or a secondary compensatory process? I will present my group’s attempts to answer these questions using computational modelling of EEG and MEG data.
Second, frontotemporal ‘dysconnectivity’ has also long been suspected to be a key problem in psychosis. It is present in several genetic mouse models of schizophrenia. We have used both spatial and associative memory tasks in MEG to try to understand the nature of this coupling problem: whether it is frequency-specific, how it impacts both encoding and/or retrieval, and whether it applies to both spatial and non-spatial (e.g. recognition and 'inferential') memory processes. |
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| responsibles | Allen |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2025/06/18 14:16 UTC |
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