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Investigations of a rare variant of VGLUT3 (p.T8I) provide a model for a molecular understanding of addiction and eating disorders and opens the doors to specific treatments| title | Investigations of a rare variant of VGLUT3 (p.T8I) provide a model for a molecular understanding of addiction and eating disorders and opens the doors to specific treatments |
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| start_date | 2022/11/18 |
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| schedule | 14h30 |
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| online | no |
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| location_info | salle Henri Gastaut |
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| details | invité par Christelle Baunez |
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| summary | Cholinergic interneurons are pivotal regulators of striatal function and have the particularity to express both the vesicular acetylcholine transporter (VAChT) and the atypical type 3 vesicular glutamate transporter (VGLUT3). We previously identified the missense polymorphism p.T8i (a change from a threonine at position 8 to an isoleucine) in patients with severe addiction or eating disorders. In this study we found: i) that this allele is causative in psychiatric disorders, ii) what are the underlying neurochemical mechanisms and iii) a treatment to alleviate ED in rodent and potentially in humans. |
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| responsibles | Riehle |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2022/11/24 14:06 UTC |
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