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Diet-induced changes to striatal circuitry and implications for behavioural control.| title | Diet-induced changes to striatal circuitry and implications for behavioural control. |
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| start_date | 2025/09/26 |
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| schedule | 11h30 |
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| online | no |
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| location_info | NC |
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| summary | Habits provide a rapid, efficient means for decision making however, this comes with a loss of behavioural flexibility. Although striatal circuits control instrumental learning including habits, little is known about how experiences that accelerate habit learning alter activity in these circuits to promote premature habitual control. Using the outcome devaluation task to distinguish flexible actions from habits, we have found that long-term access to an obesogenic diet promotes habitual behavioural control. I will present data that demonstrate changes inmicroglial activity following the obesogenic diet are largely observed in the dorsomedial striatum associated with goal-directed performance and that local inflammation in this region is sufficient to induce behavioural deficits. Importantly, pharmacologically preventing to limiting microglial changes restored goal-directed control. These results have important implications for understanding failures of behavioural control and strategies for improving behavioural flexibility. |
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| responsibles | NC |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2025/09/17 12:27 UTC |
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