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How memories can be stored and modified: decoding hippocampal algorithms during learning and sleep| title | How memories can be stored and modified: decoding hippocampal algorithms during learning and sleep |
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| start_date | 2023/02/13 |
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| schedule | 11h-12h |
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| online | no |
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| location_info | Conference room R229 |
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| summary | Making memories can be described as a two-step process. Step one is the learning – or encoding of new information in a temporary storage – the hippocampus – one of the first brain region affected by Alzheimer disease. The information can be completely new or can be a modification of an already known situation. Step two is the consolidation of such newly learnt information and their transfer into a long-term storage in the cortex, where it will be accessible for later recall if a need arises. Such transfer of information is thought to heavily relies on a good dialogue between the hippocampus and the cortex, especially during sleep. While the two-stage memory model is widely recognized, we have very little data on (i) what mechanisms support information update, (ii) how and when the hippocampo-cortical dialogue happens and (iii) how it affects the memory neural code. To finally bridge this important knowledge gap, we have concomitantly recorded from the CA1 region of the hippocampus and the medial entorhinal cortex of rats while they learn new goal locations, sleep and have their memory tested after. |
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| responsibles | Agulhon |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2023/02/03 13:51 UTC |
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