|
The effects of caffeine on synaptic plasticity and memory in the aging | title | The effects of caffeine on synaptic plasticity and memory in the aging |
|---|
| start_date | 2025/10/13 |
|---|
| schedule | 11h30 |
|---|
| online | no |
|---|
| location_info | NC |
|---|
| summary | Caffeine consumption is believed to offer protective effects against neurodegeneration associated with aging by decreasing the production of reactive oxygen species and beta-amyloid peptide. Furthermore, caffeine may enhance cognitive processes by influencing the mechanisms of synaptic plasticity that are fundamental to memory. Specifically, in the hippocampus, caffeine has the capacity to change the modulation of plasticity governed by adenosine receptors. Several studies have indicated that chronic caffeine intake can restore long-term potentiation (LTP) in the hippocampus under pathological conditions. Drawing from these findings, we examined the effects of chronic caffeine consumption on memory and hippocampal synaptic transmission in SAMP8 animals, which serve as a model for accelerated aging and neurodegeneration. We employed behavioral tests to assess recognition memory and we applied in vitro electrophysiology techniques to evaluate excitability and synaptic transmission in the hippocampus. Our results demonstrate that chronic caffeine consumption diminishes enhances hippocampal-dependent memory, and facilitates LTP in hippocampal synapses. |
|---|
| responsibles | NC |
|---|
Workflow history| from state (1) | to state | comment | date |
|---|
| submitted | published | | 2025/10/07 12:50 UTC |
| |
|