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Towards a mechanistic understanding of synapse formation| title | Towards a mechanistic understanding of synapse formation |
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| start_date | 2023/02/03 |
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| schedule | 14h30 |
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| online | no |
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| location_info | Amphithéâtre Budé |
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| details | Conférence en anglais |
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| summary | The Sudhof lab major goal is to gain mechanistic insight into how synapses are formed and eliminated during development and throughout life. Towards that goal, Sudhof and his colleagues have identified major surface-signaling proteins that also are adhesion molecules and are key components of a sophisticated nanomachine organizing synapses. Functional disruption of these proteins causes a panoply of synaptic impairments, consistent with the notion that synapses are assembled via the concerted actions of multiple signaling pathways akin to a mosaic in which each individual stone piece contributes to the overall picture. Many of the proteins Sudhof identified are involved in neurological and neuropsychiatric disorders, consistent with a central role for synapses in human diseas |
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| responsibles | Maloumian |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2023/01/26 14:25 UTC |
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