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Familial Neural Similarity as a Context-Sensitive Mechanism in Early Socioemotional Development| title | Familial Neural Similarity as a Context-Sensitive Mechanism in Early Socioemotional Development |
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| start_date | 2025/12/11 |
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| schedule | 10h30-11h30 |
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| online | no |
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| location_info | amphithéâtre Neurocampus Michel Jouvet, Bât. 462 |
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| summary | Family environments shape children’s socioemotional brain development, yet the neural pathways linking parental characteristics to child outcomes remain incompletely defined. Intergenerational transmission refers to the transfer of genetic and non-genetic influences from parents to their children. Across more than 250 family members from our SMILIES project, we introduce Familial Neural Similarity (FNS) as a novel measure of cross-generational resemblance in brain structure and function, and examine its associations with socioemotional child outcomes and contextual factors. Using structural MRI, we demonstrate that FNS is measurable and feature-specific. In the corticolimbic tract (CLT), a pathway central to socioemotional processing and mental health, biologically related parent-child dyads show greater similarity than unrelated adult-child pairs. Higher CLT similarity is further linked to children’s mental well-being, and moderated by parental early-life experiences, particularly in fathers. Functional MRI data converge with these structural findings. During socioemotional movie watching, whole-brain FNS exceeds that of unrelated pairs, with sex-specific amplification in mother-daughter and father-son dyads. Regionally, increased similarity emerges in prefrontal and temporal systems, notably the ventrolateral prefrontal cortex, where FNS further links to parent-child similarity in internalizing symptoms and is modulated by parents’ emotion-regulation strategies. Complementary data from an explicit Theory of Mind (ToM) task reveal elevated FNS in the right temporoparietal junction, a core region for mentalizing. Collectively, these findings thus establish FNS as a context-sensitive neural phenotype linking family history and experiences to children’s socioemotional brain organization and well-being. This work advances an intergenerational social neuroscience framework, moving beyond descriptive resemblance toward mechanistic understanding of how socioemotional learning and vulnerability are transmitted across generations |
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| responsibles | NC |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2025/12/08 08:21 UTC |
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