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Circuit mechanisms underlying social motivation| title | Circuit mechanisms underlying social motivation |
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| start_date | 2023/03/28 |
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| schedule | 09h30 |
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| online | no |
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| location_info | salle de conférence |
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| details | Invited by Thomas Marissal |
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| summary | The decision to approach or avoid a conspecific is fundamental for survival. Affiliative (prosocial) interactions favor approach behaviors, whileantagonistic (aggressive) contactstrigger avoidance. Here we ask how the brain encodes the valence of social interaction. We focused on the nucleus accumbens (NAc), a brain region implicated in social reward processing. We observed that social interactions activateD1-expressing medium spiny neurons (D1-MSNs)regardless of their valence. However, afferentD1-expressingneurons of the anterior insular cortex (AIC) exhibited distinct activity patterns coding for prosocial and aggressive social interaction, respectively. As a result, distinct forms of synaptic plasticity were elicited atthe AIC to NAc synapses. Thus, the valence ofsocial interaction induces distinct neural activity in the AIC, which teaches the animal to approach and avoid conspecifics in the future. |
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| oncancel | changement d'horaire |
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| responsibles | Burban |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2023/03/23 13:24 UTC |
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