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Dopamine D2 receptors in the extended amygdala scale the optimization of seeking and avoidance behaviors| title | Dopamine D2 receptors in the extended amygdala scale the optimization of seeking and avoidance behaviors |
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| start_date | 2023/04/25 |
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| schedule | 11h (à confirmer) |
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| online | no |
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| location_info | Amphithéâtre Serge Kampf |
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| summary | The ability to optimize and select behavioral strategies is a cardinal and conserved psychophysiological feature for maximizing the chances of survival.
Increasing evidence suggests that the mesolimbic dopamine system contributes to these processes. I will discuss recent findings suggesting that such optimization relies on dopamine D2 receptors (D2R) within a subcircuit spanning across the extended amygdala (EA) and the tail of the striatum (TS). Using a mouse model carrying a temporally controlled deletion of D2R within a subcircuit defined by WFS1 neurons, I'll illustrate that intact EA D2R signaling is necessary to regulate homeostasis-dependent food-seeking behaviors in both male and female mice as well as active avoidance learning and innate escape responses in males. |
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| responsibles | Sadoul |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2023/04/20 13:07 UTC |
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