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In silico modeling of brain microvascular function to highlight the overlap between cerebrovascular and Alzheimer’s Disease.| title | In silico modeling of brain microvascular function to highlight the overlap between cerebrovascular and Alzheimer’s Disease. |
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| start_date | 2026/04/24 |
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| schedule | 11h30 |
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| online | no |
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| location_info | NC |
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| summary | The cerebral microvascular system is essential to a large variety of physiological processes in the brain, including blood delivery, neurotoxic waste clearance and blood flow regulation as a function of neuronal activity (neuro-vascular coupling). It also plays a major role in disease (stroke, neurodegenerative diseases, …). However, the functional consequences of vascular damage (including acute occlusions or long-term remodeling in ageing or disease) are poorly understood.
In this context, in silico modeling approaches are increasingly important, and enable to integrate the specific multi-scale architecture of the brain microvascular network with the physics of blood flow in confined conditions. I will discuss how the resulting scaling-laws for blood flow and molecular transport are mostly driven by the topology of the microvascular network, deterministically leading to the emergence of hypoxic pockets in sub-cortical regions under mild hypoperfusion. I will highlight how these results help understand the overlap between cerebrovascular and Alzheimer’s Disease. |
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| responsibles | NC |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2026/03/31 13:22 UTC |
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