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Differential role of nociceptors in skin inflammation| title | Differential role of nociceptors in skin inflammation |
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| start_date | 2023/05/11 |
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| schedule | 11h30-12h30 |
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| online | no |
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| location_info | Amphithéâtre Serge Kampf |
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| summary | Sensing and integration of environmental cues (e.g., presence of contact allergens or tissue damage) by skin-resident structural, neuronal and immune cells allow to trigger appropriate response and maintain homeostasis. Dysregulation of this equilibrium can contributes to the development of allergic skin inflammation. New findings have shown that, in addition to modulate sensations, nociceptive sensory neurons also have the potential to influence immune cells and associated inflammation. In our work, we explore the role of nociceptors in mouse models of multiple inflammatory skin diseases, including atopic dermatitis and allergic contact dermatitis. We could show that their activation plays opposite role in the two diseases through different type of neuroimmune interactions. In a model of atopic dermatitis in mice, we could show that recognition of allergens in the skin by a “sensory unit” composed of nociceptors and mast cell could initiate the development of the inflammatory response in the skin. The blockade of interactions between mast cells and nociceptors could prevent the development of the disease. In an allergic contact dermatitis model in mice, we could show that activation of nociceptors is associated with the induction of a “nerve regeneration” transcriptomic program in the nerve innervating the skin. On the opposite of what we saw for atopic dermatitis, we could show that genetic ablation of nociceptors induced an increased inflammatory response, with an increased recruitment of neutrophils. Our data thus suggest that the expression of a “nerve injury” transcriptomic program in skin-innervating nociceptors during allergic contact dermatitis could also drive an anti-inflammatory phenotype of this nociceptors. |
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| responsibles | Sadoul |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2023/05/04 14:02 UTC |
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