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Sleep, Sedation and the Basal Ganglia| title | Sleep, Sedation and the Basal Ganglia |
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| start_date | 2023/06/21 |
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| schedule | 15h |
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| online | no |
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| location_info | Bât. 462 - Amphithéâtre Neurocampus Michel Jouvet |
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| summary | Current models of sleep physiology traditionally ignore the basal ganglia and the dopamine
systems. This is surprising given the known effects of dopaminergic stimulants and the sleep
disorders commonly associated with Parkinson’s disease. In my seminar I will outline the
sleep related changes in the discharge of neurons in the basal ganglia networks of non-
human primates before and following MPTP intoxication and the development of clinical
symptoms of Parkinson’s disease, including insomnia. I will use the model of the basal
ganglia as a reinforcement learning network to discuss if the changes in the activity of
neurons in the main axis of the basal ganglia are due to changes in their critic/teacher (e.g.
dopaminergic activity) or thalamo/cortical inputs. Finally, I will introduce novel methods for
closed loop deep brain stimulations and discuss how they may be used to stop/slow the
progression from REM sleep behavior disorders to Parkinson’s disease. |
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| responsibles | Information non disponible |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2023/06/19 12:54 UTC |
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