Expression profile of clustered protocadherins in the mouse hippocampus and their role in engram formation and memory processes

titleExpression profile of clustered protocadherins in the mouse hippocampus and their role in engram formation and memory processes
start_date2026/07/16
schedule11h
onlineno
location_infoamphithéâtre Neurocampus Michel Jouvet, Bât. 462
summaryClustered protocadherins, a family of cell-surface proteins, generate unique neuronal identities through combinatorial expression. A recent study shows that gamma isoforms are enriched in recently activated neurons. Genetic manipulation of their diversity disrupts engram formation, reactivation, and function, leading to memory deficits. These findings reveal that clustered protocadherins act as a dynamic molecular code regulating memory processes.
responsiblesNC