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Tripartite anteroposterior organization of macaque lateral prefrontal cortex: posterior–mid dominance and frontopolar task-related deactivation| title | Tripartite anteroposterior organization of macaque lateral prefrontal cortex: posterior–mid dominance and frontopolar task-related deactivation |
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| start_date | 2026/09/03 |
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| schedule | 15h15 |
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| online | no |
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| location_info | Room B10 |
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| summary | The lateral prefrontal cortex (LPFC) supports diverse cognitive functions, yet how these functions are organized across its broad cortical extent remains unclear. We recorded single-neuron activity across nearly the full anteroposterior and mediolateral extent of macaque LPFC, including the frontopolar cortex (FPC), while animals performed eight cognitive tasks. We decomposed these tasks into 29 component functions spanning basic sensorimotor-linked operations to higher-order integrative processes, and mapped neuronal recruitment for each function across the LPFC. The principal functional gradient ran along the anteroposterior axis. Sensorimotor-linked functions were concentrated posteriorly, whereas higher-complexity functions peaked more anteriorly within mid-LPFC. Strikingly, however, functions previously associated with the monkey FPC—including resource allocation, exploration, and self-generated decision monitoring—as well as other higher-order functions, did not peak in the FPC. Instead, neuronal recruitment declined toward the frontal pole, where task-related deactivation was frequently observed. These findings reveal a tripartite organization of macaque LPFC, comprising posterior sensorimotor, mid-LPFC higher-order control, and frontopolar task-negative (DMN-like) territories. This organization provides a cellular-level framework for considering how macaque and human prefrontal organizations may differ. |
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| responsibles | Allen |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2026/08/25 12:27 UTC |
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