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Role of astrocyte JAK-STAT signaling in the regulation of mouse socio-sexual behaviortitle | Role of astrocyte JAK-STAT signaling in the regulation of mouse socio-sexual behavior |
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start_date | 2023/09/29 |
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schedule | 14h30 |
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online | no |
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location_info | Salle Henri Gastaut |
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summary | Social behaviors including mating, parenting and social interactions are crucial for the survival and health of many species. Accumulating evidence indicates that the immune system acts as a neuromodulator to regulate mouse behavior, including social interactions, through cytokine signaling. In the central nervous system, astrocytes are important mediators of cytokine signaling notably through activation of the JAK-STAT pathway. Moreover, astrocytes influence various physiological behaviors in a brain-region specific manner through a finely tuned regulation of synaptic transmission. Therefore, we hypothesize that local astrocytes might play a key role in cytokine-mediated regulation of mouse social behavior. Our results show that social interaction activates the JAK-STAT pathway in astrocytes of the mouse ventral hippocampus (vHPC). Furthermore, we found that activating this cascade specifically in vHPC astrocytes selectively promotes mouse socio-sexual behavior. Our current experiments aim at deciphering the functional changes elicited by astrocyte JAK-STAT pathway at the local- and circuit-levels. |
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responsibles | Riehle |
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Workflow historyfrom state (1) | to state | comment | date |
submitted | published | | 2023/09/06 14:04 UTC |
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