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Immunological checkpoints in wound healing and misregulated reparative responses| title | Immunological checkpoints in wound healing and misregulated reparative responses |
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| start_date | 2024/02/06 |
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| schedule | 18h-19h30 |
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| online | no |
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| location_info | / |
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| summary | Poor wound healing and its consequences on health and morbidity are one of the major unresolved medical problems today. Therefore, pharmaceutical advances to boost endogenous regenerative responses and to prevent misregulated reparative responses as e.g. tissue fibrosis are milestones in medicine. Yet, any therapeutic intervention would have to be carefully designed to accommodate the spatial-temporal complexity of intercellular metabolic interactions in the wound environment and to prevent neoplastic growth.
Frequently, impaired wound healing is associated with immune dysfunction leading to prolonged inflammation and tissue damage with a spectrum of pathological outcomes. An ulcerative healing defect in barrier organs (e.g. chronic wounds in the skin, mucosa, or cornea) and the excessive formation of ECM with perturbed architecture leading to organ fibrosis (e.g. hypertrophic scarring of the skin, keloid formation, or scleroderma) represent extremes on this spectrum. The underlying molecular pathology is not resolved and requires deeper mechanistic investigation. Findings generated in the Eming group demonstrate that metabolic pathways in immune cells or stromal cells control the outcome of a tissue damage response and that metabolic dysbalance in these cell types provides an explanation for the spectrum of pathological repair phenotypes. Specifically, using a combination of gene-modified mouse models and transcriptome profiling, the Eming group showed that metabolic reprogramming in macrophages coordinates critical stage-specific repair processes during wound healing. These findings may unravel useful targets for therapeutic innovation, which will be presented and discussed. |
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| responsibles | Pradeu |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2024/01/31 16:04 UTC |
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